Search results for " UPR"

Archeologia dziewiętnastowiecznej pamięci w insurekcyjnym tryptyku Jarosława Iwaszkiewicza ("Noc czerwcowa", "Zarudzie", "Heydenreich")

2013

Three short “insurrection” stories written by Jarosław Iwaszkiewicz in the years 1963–1974 have inspired various interpretations; it seems, however, that there are still many undeciphered codes, references, and allusions. The author’s metatextual comments as well as the implicit poetics of the stories make it possible to consider them as a dialogue with the historical, cultural and aesthetic heritage of the 19th century: as a form of its literary archeology. The article deals with many literary and aesthetic conventions employed in the stories, with the emphasis on the concept of sérénité and on various associations with 19th-century art. Notably, the scope of analysis includes such motifs …

Józef Wacław Dąbrowski (1797–1862). Wołynianin w armii Królestwa Polskiego

2021

W artykule, w oparciu o nieznane i tym samym niewykorzystywane dotąd przez historyków wspomnienia, przedstawione zostały dzieciństwo i młodość Józefa Wacława Dąbrowskiego, oficera wojska Królestwa Polskiego, dowódcę w randze kapitana i majora oddziałów powstańczych jesienią 1830 – latem 1831 r. Koleje jego losów i kariera wojskowa są tak typowe, jak i odbiegające od znanych i omawianych w literaturze przedmiotu schematów. Typowe, gdyż dzięki wywodzeniu się z kręgów średnio zamożnego ziemiaństwa rozpoczął służbę wojskową od stopnia kadeta, aby przed upływem roku awansować na podchorążego i uzyskać skierowanie do szkoły podchorążych, stanowiącej niezbędny etap służby potrzebny do awansu ofice…

Thioredoxin (Trxo1) interacts with proliferating cell nuclear antigen (PCNA) and its overexpression affects the growth of tobacco cell culture.

2017

Thioredoxins (Trxs), key components of cellular redox regulation, act by controlling the redox status of many target proteins, and have been shown to play an essential role in cell survival and growth. The presence of a Trx system in the nucleus has received little attention in plants, and the nuclear targets of plant Trxs have not been conclusively identified. Thus, very little is known about the function of Trxs in this cellular compartment. Previously, we studied the intracellular localization of PsTrxo1 and confirmed its presence in mitochondria and, interestingly, in the nucleus under standard growth conditions. In investigating the nuclear function of PsTrxo1 we identified proliferati…

AtCCS is a functional homolog of the yeast copper chaperone Ccs1/Lys7

2005

AbstractIn plant chloroplasts two superoxide dismutase (SOD) activities occur, FeSOD and Cu/ZnSOD, with reciprocal regulation in response to copper availability. This system presents a unique model to study the regulation of metal-cofactor delivery to an organelle. The Arabidopsis thaliana gene AtCCS encodes a functional homolog to yeast Ccs1p/Lys7p, a copper chaperone for SOD. The AtCCS protein was localized to chloroplasts where it may supply copper to the stromal Cu/ZnSOD. AtCCS mRNA expression levels are upregulated in response to Cu-feeding and senescence. We propose that AtCCS expression is regulated to allow the most optimal use of Cu for photosynthesis.

Experimental increase in fecundity causes upregulation of fecundity and body maintenance genes in the fat body of ant queens.

2021

In most organisms, fecundity and longevity are negatively associated and the molecular regulation of these two life-history traits is highly interconnected. In addition, nutrient intake often has opposing effects on lifespan and reproduction. In contrast to solitary insects, the main reproductive individual of social hymenopterans, the queen, is also the most long-lived. During development, queen larvae are well-nourished, but we are only beginning to understand the impact of nutrition on the queens' adult life and the molecular regulation and connectivity of fecundity and longevity. Here, we used two experimental manipulations to alter queen fecundity in the ant Temnothorax rugatulus and …

Nitric oxide and glutathione impact the expression of iron uptake- and iron transport-related genes as well as the content of metals in A. thaliana p…

2012

International audience; Mounting evidence indicate that nitric oxide (NO) acts as a signaling molecule mediating iron deficiency responses through the upregulation of the expression of iron uptake-related genes. Accordingly, NO donors such as nitrosoglutathione (GSNO) were reported to improve the fitness of plants grown under iron deficiency. Here, we showed that glutathione, a by-product of GSNO, triggered the upregulation of the expression of iron uptake- and transport-related gene and an increase of iron concentration in Arabidopsis thaliana seedlings facing iron deficiency. Furthermore, we provided evidence that under iron deficiency, NO released by GSNO did not improve the root iron co…

γ-Glutamyl cysteine suppresses TNF-α up-regulation via protein phosphatases in acute pancreatitis

2016

Echovirus 1 internalization negatively regulates epidermal growth factor receptor downregulation

2016

We have demonstrated previously that the human picornavirus Echovirus 1 (EV1) triggers an infectious internalization pathway that follows closely, but seems to stay separate, from the epidermal growth factor receptor (EGFR) pathway triggered by epidermal growth factor (EGF). Here, we confirmed by using live and confocal microscopy that EGFR and EV1 vesicles are following intimately each other but are distinct entities with different degradation kinetics. We show here that despite being sorted to different pathways and located in distinct endosomes, EV1 inhibits EGFR downregulation. Simultaneous treatment with EV1 and EGF led to an accumulation of EGFR in cytoplasmic endosomes, which was evi…

Constitutive activation of MexT by amino acid substitutions results in MexEF-OprN overproduction in clinical isolates of Pseudomonas aeruginosa

2018

ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.

Injury-activated glial cells promote wound healing of the adult skin in mice

2018

Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously…